| 摘要: |
| 适配体作为传统抗体的替代物，在药物残留检测、临床诊断、靶向治疗等许多领域有广范的应用。适配体与生物传感器检测技术相结合，可研制出一系列适配体传感器。介绍了适配体的概念和优点，适配体传感器的种类，如荧光传感器、电化学传感器、比色传感器、SERS（Surface Enhanced Raman Scattering）传感器和SPR（Surface Plasmon Resonance）传感器，以及它们的原理、检测限和应用情况，展望适配体传感器在兽药残留检测和动物疾病诊断等方面的应用前景。 |
| 关键词: 适配体 传感器 应用前景 |
| DOI： |
| 投稿时间：2011-03-14修订日期：2011-04-19 |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目）；北京市属高校人才强教计划资助项目PHR(IHLB2009-07135)；北京市自然科学基金（6092004，5102014）；北京市教委（KM 201010020008） |
|
| Advance in aptamer-based biosensors |
| Zhu wenqi |
| (Bei University of Agriculture) |
| Abstract: |
| As antibody’s substitute, aptamer has wide perspective on veterinary drugs detection, clinic diagnose, targeted therapy. Aptamer-based biosensers had been prepared with aptamers binding to biosensors. The concept of aptamer, its advantages, and principle,detectability,application of the different aptamer-based biosensors ,which are fluorescence biosensors,electrochemical biosensors,colorimetric sensors,SERS biosensors and SPR biosensors were summarized. The perspective of aptamer-based biosensors were reviewed on detection of veterinary drug residue, and diagnosis of animal diseases. |
| Key words: aptamer biosensor perspective |
