新型佐剂狂犬病灭活疫苗的研制

Development of Rabies Inactivated Vaccine with a New Type Adjuvant

关键词:  狂犬病灭活疫苗  佐剂  免疫试验

Key words:  Rabies inactivated vaccines  adjuvant  immune test

摘要:

利用反向遗传操作系统拯救出狂犬病毒的携带双G基因的HEP-dG株,选用新型佐剂制成狂犬病灭活疫苗，进行小鼠免疫试验、比格犬最小免疫剂量试验、免疫持续期试验。试验表明，携带双G基因的HEP-dG株具有良好的免疫原性，该新型佐剂狂犬病灭活疫苗免疫效果较好，具有完全的保护力和较长的免疫保护持续期。

Abstract:

Recombinant HEP-dG Rabies virus stock was rescued by the technique of reverse genetics，inactivated rabies vaccines with a new trpe adjuvant for immune test were conducted in mice and the minimum immune dose test were conducted in Beagle. The results demonstrated that recombinant HEP-dG Rabies virus strain has good immunogenicity，and the Rabies inactivated vaccines were effective and protective.