小反刍兽疫活疫苗的安全性评价试验

The security assessment test of Peste des petits ruminants vaccine

关键词:  小反刍兽疫 疫苗 安全

Key words:  Peste des petits ruminants (PPR)  vaccine  security

摘要:

小反刍兽疫（PPR）是由小反刍兽疫病毒（Peste des petits ruminants virus PPRV）引起的一种急性、烈性、接触性传染病。2007年PPR在我国西藏首次暴发，我国使用PPR Nigeria 75/1疫苗株制造的疫苗在西藏和新疆部分地区进行免疫接种。为明确疫苗的安全性，本实验室对其安全性能进行了系统评价。试验结果表明，健康易感山羊、绵羊及怀孕山羊、绵羊按不同剂量接种疫苗后，均未观察到异常临床反应；怀孕母羊所产羔羊数量与对照无明显差异。用小鼠、豚鼠进行疫苗非特异性安全评价表明，所有接种动物均健活。试验表明该疫苗安全性良好，可在田间大规模使用。

Abstract:

Peste des petits ruminants (PPR) caused by peste des petits ruminants virus (PPRV), is an acute and highly contagious viral disease of small ruminants such an sheep and goats and causes great economic impact on livestock industry. In 2007, It was reported in Tibet of china, and PPR vaccine of Nigeria 75/1 strain was used in Tibet and part of Xinjiang. To evaluate vaccine security, the trials of vaccine security were carried out. The results show that the sheep and goat inoculated PPR vaccine by different dose were not observed any abnormal symptom; the same as pregnant sheep and goat. And the number of lambs is nondiscriminatory compared with the control. The nonspecific safety evaluation shows the mouse and cavy inoculated PPR vaccine are all healthy living, which shows that the PPR vaccine is security, and can be used on a large scale in fields.