| 摘要: |
| 对不同保存年代的鸡新城疫疫苗种毒HB1株（Ⅱ系）和F株（Ⅲ系）各3批进行了病毒含量测定和免疫原性试验。3批不同保存年代的鸡新城疫病毒HB1株和F株病毒含量均≥108.4EID50/0.1mL，最小免疫量均≤2500EID50。结果表明鸡新城疫病毒HB1株和F株毒种在-70℃分别保存16年和19年病毒含量和免疫原性仍符合《中华人民共和国兽用生物制品规程》（二〇〇〇年版）规定。 |
| 关键词: 鸡新城疫疫苗种毒 保存期 病毒含量 免疫原性 |
| DOI： |
| 投稿时间：2010-04-09修订日期：2010-11-29 |
| 基金项目: |
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| Studies on Preservation Period of Master Seeds of Newcastle Disease Live Vaccines Strain Virus HB1 and F |
| wutao |
| (China Institute of Veterinary Drug Control) |
| Abstract: |
| The virus titers and immunogenicity of three batches master seeds of Newcastle disease live vaccine strain virus (HB1,class Ⅱ & F,class III; stored in -70℃ for different times) has been tested. The virus titers were all above 108.4EID50/0.1mL and the immune minimum doses were all below 2500EID50. It show that the virus content and immunogenicity of the master seeds of Newcastle Disease virus (HB1,class Ⅱ & F,class III) stored in -70℃ for 16 years or 19 years still conformed the regulations of The People's Republic of China Veterinary Biological Products ,2000 edition. |
| Key words: Master Seeds of Newcastle Disease Live Vaccine Preservation Period Virus titers Immunogenicity |
