托芬那酸的药理毒理研究资料综述

Review of Pharmacology and Toxicology of Tolfenamic Acid

关键词:  托芬那酸  药效  药动学  作用机制  急性毒性  慢性毒性  生殖毒性

Key words:  Tolfenamic Acid  pharmacodynamics  pharmacokinetics  mechanism of action  acute toxicity  chronic toxicity  reproductive toxicity

摘要:

综述了非甾体抗炎药托芬那酸的药理毒理研究资料，为托芬那酸的临床应用等提供参考。与其它的非甾体抗炎药类似，托芬那酸具有抗炎、镇痛及解热作用。通过抑制环氧化酶(COX)减少花生四烯酸(AA)向炎症介质前列腺素(PGs)转化而起到消炎镇痛作用。托芬那酸在动物体内吸收迅速，广泛分布于各种组织中，代谢速度相对较快。在安全药理、急慢性毒性、致突变及生殖毒性方面，没有严重的特异性的毒性反应。

Abstract:

Abstract: This is a review of pharmacology and toxicology of tolfenamic acid. It can provide references for the applications of tolfenamic acid. Similar to other non-steroidal anti-inflammatory drugs(NADA), tolfenamic acid can exert anti-inflammatory, analgesic and antipyretic properties.The principal mode of action of tolfenamic acid is thought to be similar to other NSAIDs since it inhibits cyclo-oxygenase and thus reduces the synthesis of important inflammatory mediator eicosanoids such as prostaglandins. Tolfenamic acid can be absorped rapidly and widely distributed in all tissues. The speed of its metabolism is fairly fast. According to many documents, tolfenamic acid can't lead to serious specific toxic reaction in aspects of safety pharmacology, acute toxicity, chronic toxicity and reproductive toxicity.