壳聚糖絮凝对双黄连口服液制剂中有效成分的影响

Effects of Chitosan on Active Constituent in Shuanghuanglian Koufuye

关键词:  壳聚糖  澄清剂  正交试验  双黄连口服液

Key words:  chitosan  clarifying agent  orthogonal experiment  Shuanghuanglian Koufuye

摘要:

选用正交试验筛选壳聚糖絮凝澄清的最佳条件，以主要成分黄芩苷作为含量考察指标，研究了壳聚糖作为澄清剂对双黄连口服液中黄芩苷含量的影响，并与醇沉法进行了对比。结果显示，壳聚糖能使双黄连提取液得到良好的澄清效果，主要成分黄芩苷损失较小，优于醇沉法，表明壳聚糖能作为良好的澄清剂代替醇沉法处理双黄连口服液。

Abstract:

The effects of chitosan as clarifying agent on Shuanghuanglian Koufuye were studed with the content of baicalin as a reference. The optimum conditions were selected by orthogonal experiment. Results showed that compared with the precipitated method by alcohol, the loss of baicalin was comparatively less when using chitosan It suggested that chitosan could be used to clarify the extracts of Shuanghuanglian Koufuye.