| 摘要: |
| 以阿苯达唑为原料，采用一锅合成法，通过氧化、酸化反应得到目标产物盐酸阿苯达唑亚砜。采用丙酮为反应溶剂，当阿苯达唑和盐酸的投料比为30g:13ml，阿苯达唑和双氧水的投料比为1:1.01（n:n），反应时间为30min时，制备的盐酸阿苯达唑亚砜的收率为95.87%，通过IR，1H-NMR，13C-NMR和ESI-MS分析对其产物结构进行了确证。 |
| 关键词: 阿苯达唑 盐酸阿苯达唑亚砜 合成 |
| DOI： |
| 投稿时间：2009-11-13修订日期：2009-11-23 |
| 基金项目:国家科技支撑计划（2006BAD31B04）资助项目 |
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| Synthesis of Albendazole Sulfoxide Hydrochloride |
| liuzhiliang |
| (Shandong Sinder Technology corporation) |
| Abstract: |
| Albendazole Sulfoxide Hydrochloride was syntheiszed by oxidation and acidification using albendazole as raw materials, by one-step synthesis method. The yield of Albendazole Sulfoxide Hydrochloride was 95.87% when the feed ratio of Albendazole to hydrochloride was 30g:13ml, the feed ratio of Albendazole to hydrogen peroxide was 1:1.01, the reaction time was 30min. The structure of target substance was determined by IR, 1H-NMR, 13C-NMR and ESI-MS. |
| Key words: Albendazole Albendazole Sulfoxide Hydrochloride synthesis |
