氟苯尼考磺酸盐在肉鸡体内的药物动力学初步研究

Preliminary studies on the Pharmacokinetics of florfenicol sulfonate in broiler chickens

关键词:  氟苯尼考磺酸盐 氟苯尼考 药动学 健康三黄肉鸡

Key words:  florfenicol sulfonate florfenicol pharmacokinetics broiler chickens

摘要:

为研究氟苯尼考磺酸盐在肉鸡体内的血药浓度及药动学特征，将12只健康三黄肉鸡，单次肌肉注射推荐治疗剂量（20mg•kg-1）的自制2％氟苯尼考磺酸盐。采用高效液相色谱法测定血浆药物浓度，最低检测限为0.05μg•mL-1，所得数据用3P97药动软件进行分析后发现，血药浓度和时间关系符合一级吸收一室模型，选择的权重为1/C。主要药动学参数为T1/2kα：(0.28±0.04)h，T1/2Ke：(2.06±0.06)h，Cmax：(4.17±0.12)μg•mL-1，Tpeak：(0.92±0.09)h，AUC：(16.89±0.35)μg•mL-1•h，V/F(c)：(3.52±0.13)L•kg-1，CL/F(s)：(1.19±0.03)L•kg-1•h-1，Ke：(0.34±0.01)h-1，kα：(2.57±0.37)h-1，A：(6.56±0.38)μg•mL-1。结果提示，氟苯尼考磺酸盐在肉鸡体内具有吸收迅速，分布广泛、峰浓度较高以及消除较快的动力学特征。

Abstract:

Twelve broiler chickens were investigated the pharmacokinetics of florfenicol sulfonate after single intramuscular at a dosage of 20 mg•kg-1. The concentrations of florfenicol sulfonate in plasma were determined by HPLC with detection limit of 0.05μg•mL-1. The pharmacokinetics parameters were calculated by 3p97 computer program and fitted a one-compartment open model with weight by 1/C. The main parameters of florfenicol sulfonate in broiler chickens were as follows: T1/2kα: (0.28±0.04)h, T1/2Ke: (2.06±0.06)h, Cmax: (4.17±0.12)μg•mL-1, Tpeak: (0.92±0.09)h, AUC: (16.89±0.35)μg•mL-1•h, V/F(c): (3.52±0.13)L•kg-1, CL/F(s): (1.19±0.03)L•kg-1•h-1, Ke: (0.34±0.01)h-1, kα: (2.57±0.37)h-1, A: (6.56±0.38)μg•mL-1. The results showed that the distribution of florfenicol sulfonate was rapid and wide in the broiler chickens , the concentration of plasma was high and elimination was quick.