诺氟沙星诱导水生细菌产生耐药性的最低选择浓度的调查

Investigation of the minimal selective concentration of norfloxacin for inducing resistance in aquatic bacteria

关键词:  诺氟沙星  残留  耐药性  水生细菌

Key words:  Norfloxacin  residue  resistance  aquatic bacterium

摘要:

摘要：渔药多以拌料或直接投入水体的方式给药，兽药经动物排泄出体外最终也将进入土壤和表层水体中，造成药物在表层水体等生态环境中残留。药物在生态环境中残留诱导环境细菌产生耐药性，而且耐药性可能通过食物链、环境或者动物和人的直接接触进行传递。为了了解诺氟沙星在池塘水体中残留对水生细菌的影响，本试验采用琼脂稀释法对水生细菌进行了抗菌药物敏感性试验。结果表明，诺氟沙星诱导水生细菌产生耐药性的最低选择浓度为8μg/mL。

Abstract:

Abstract: It is known the fishery drugs enter into water directly when them were fed, moreover, the most of drugs are excreted out from the animal body and entered into environment especially soil and water when the them are administered in animals, which may bring about environmental pollution. The drugs induced resistance in bacteria while them entered into environment, and the resistance of bacteria would tranced between envirnment, animals and human. The antimicrobial susceptibilities of aquatic bacteria were investigated by the agar dilution method to study the effect of norfloxacin on aquatic bacteria. The results showed that the value of the minimal selective concentration (MSC) induced resistance of norfloxacin was 8µg/g on aquatic bacteria.