| 摘要: |
| 观察牛磺酸对大鼠马杜霉素中毒时的保护作用。将试验大鼠每天灌服马杜霉素进行染毒，且染毒前1h腹腔注射牛磺酸保护，染毒5d，继续注射牛磺酸2d后处死，测定血清、肝脏、腿肌和心肌的丙二醛(MDA)含量、超氧化物歧化酶(SOD)活性、谷胱甘肽过氧化物酶(GSH-Px)活力和总抗氧化能力(T-AOC)。结果表明牛磺酸保护组大鼠血清、肝脏、腿肌和心肌中SOD活性、GSH-Px活力、T-AOC均有所提高，与对照组、染毒组比较，差异显著(P<0.01，P<0.05)。牛磺酸可以提高大鼠机体的抗氧化能力，对马杜霉素引起的脂质过氧化具有保护作用。 |
| 关键词: 牛磺酸 马杜霉素 大鼠 抗氧化 |
| DOI： |
| 投稿时间：2008-12-05修订日期：2008-12-25 |
| 基金项目: |
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| Protective effects of taurine on toxic rats induced by maduramicin |
| sushuai |
| (College of veterinary medicine Youzhou university) |
| Abstract: |
| In order to observe the protective effects of taurine on toxic rats induced by maduramicin. SD rats were given taurine by intraperitoneal injection, and were given maduramicin by oral after 1 hours. Rats were induced by maduramicin for 5 days, but were given by taurine for 7 days. The concentration of MDA, and the activity of SOD, GSH-Px, and T-AOC in serum, liver, skeletal muscle and myocardium were measured respectively. The results show that the activity of SOD, GSH-Px and T-AOC in protected groups by taurine increased and the concentration of MDA decreased significantly (P<0.01, P<0.05) compared with the induced group by maduramicin. Taurine could increase antioxidative effects and reduce lipid peroxidation in toxic rats induced by maduramicin. |
| Key words: taurine maduramicin rat antioxidative |
