磺胺甲噁唑在大菱鲆体内药代动力学及残留消除规律的研究

Pharmacokinetics and Elimination of Sulfamethoxazole in Turbot

关键词:  磺胺甲噁唑  大菱鲆  药代动力学  消除  高效液相色谱法

Key words:  Qu zhina, Zhao Sijun, Wang Yudong,Lu Ping, Li Cunjin, Tan Weiquan, Sun Xiaoliang, Zheng Zengren

摘要:

采用高效液相色谱法，对以80 mg/kg b.w.单剂量口灌磺胺甲噁唑的大菱鲆进行连续采样监测，研究大菱鲆口服磺胺甲噁唑的药代动力学特征及残留消除规律。结果表明，磺胺甲噁唑在大菱鲆血液、肌肉中药代动力学特征分别符合带时滞的一级吸收二室开放模型、一级吸收一室开放模型。磺胺甲噁唑在大菱鲆体内消除速度较慢，16℃水温的实验条件下，在大菱鲆肌肉中的休药期为27天。

Abstract:

The residue of SMZ in turbot which was exposured to 80 mg/kg b.w. SMZ solution was monitored continually by HPLC, and the pharmacokinetics and elimination of SMZ in turbot after oral administration were studied. The result showed that the concentration-time course of the drug conformed to the characteritics of the two compartment open model with the first order absorption and a lagtime for the blood, and the one compartment open model with first order absorption and a lagtime for the muscle. SMZ was slowly eliminated in turbot. The concerntration of SMZ in the muscle was below LOD after 27d。