| 摘要: |
| 摘要 目的：增加妥曲珠利的溶出度，加速药物在体内的溶解，吸收，以提高妥曲珠利的生物利用度。方法：以聚乙二醇6000为载体，加入助溶剂Z，采用熔融法制备妥曲珠利固体分散体，以正交实验的方法确定出最优条件，测定妥曲珠利固体分散体与原料药的溶解度以及固体分散体体外溶出度，并对固体分散体进行稳定性考察。结果：本实验确定的最优处方为：妥曲珠利：PEG-6000：助溶剂Z= 1：6：1.6(g/g)。妥曲珠利原料药在水中溶解度为4.12×10-4g/L；妥曲珠利- PEG-6000(1:6)的溶解度为0.78g/L，体外溶出度达到88.75%。初步稳定性实验结果表明妥曲珠利固体分散物比较稳定，在水溶液中可以稳定存在。结论：将妥曲珠利制备成固体分散剂可以很好的提高其溶出度 |
| 关键词: 妥曲珠利 固体分散物 溶出度 稳定性 |
| DOI： |
| 投稿时间：2008-09-03修订日期：2009-01-04 |
| 基金项目: |
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| Preparation of toltrazuril solid dispersion |
| qiwenwen |
| (Wuhan institute of technology) |
| Abstract: |
| Abstract: Objection: To increase the dissolution of toltrazuril , accelerate the dissolution and absorption of the drug in vivo and improvement of the bioavailability of toltrazuril. Method: PEG-6000 as the carrier, adding hydrotropy agent Z, using of the melting method to prepare toltrazuril solid dispersion, the optimal conditions was chosen by orthogonal experiments. the solubility of toltrazuril raw materials and Solid dispersion, and the latter’s dissolution in vitro were detected; Besides, its stability was determined. Results: The optimal condition was: toltrazuril:PEG-6000: hydrotropy agent Z = 1:6:1.6(g/g), toltrazuril in water was 4.12×10-4g/L, the solubility of toltrazuril-PEG-6000(1:6) was 0.078 g/L, and the toltrazuril solid dispersion’s dissolution in vitro was 88.75%, the result showed that toltrazuril solid dispersion was relatively stable and it could exist in water. Conclusion: toltrazuril solid dispersion can increase its dissolution |
| Key words: Toltrazuril Solid dispersion Dissolution Stability |
