新型免疫佐剂--CpG寡脱氧核苷酸

A New Immune Adjuvant—CpG Oligodeoxynucleotides

关键词:  佐剂  CpG  寡核苷酸

Key words:  Adjuvant  CpG  oligodeoxynucleotide

摘要:

含未甲基化CpG基序的寡脱氧核苷酸能够直接刺激B细胞等抗原递呈细胞，提高Th1产量并促进细胞因子的产生及抗原递呈细胞的成熟和活化。这使CpG 寡核苷酸具有良好的免疫佐剂活性，能够促进和提高抗原特异性免疫应答。本篇综述着重介绍了CpG寡核苷酸作为免疫佐剂的研究进展。

Abstract:

Oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate B cells and other professional antigen-presenting cells, thereby promoting the production of Th1 and proinflammatory cytokines and the maturation or activation of professional antigen-presenting cells. These activities enable CpG ODNs to act as immune adjuvants, accelerating and boosting antigen-specific immune responses. This review will highlight the recent uses of CpG DNA as an immune adjuvant.