穿心莲内酯磺化物注射液解热镇痛抗炎作用研究

Study on Antipyretic Analgesic and Anti-inflammatory Effects of Andrographolide Sulfonate Injection

关键词:  解热  镇痛  抗炎  穿心莲内酯磺化物注射液

Key words:  antipyretic  analgesic  anti-inflammatory  andrographolide sulfonate injection

摘要:

为探究穿心莲内酯磺化物注射液的解热、镇痛、抗炎作用，将SD大鼠和KM小鼠分别随机分为空白组，阳性药穿心莲注射液组，穿心莲内酯磺化物注射液高、中、低剂量组。通过皮下注射干酵母诱导大鼠发热模型探究其解热作用；通过冰醋酸致小鼠扭体法探究其镇痛作用；通过二甲苯诱导小鼠耳肿胀法及λ-角叉菜胶诱导大鼠足肿胀法探究其抗炎作用。结果表明，穿心莲内酯磺化物注射液可显著抑制干酵母所致发热大鼠的肛温上升；显著抑制冰醋酸所致小鼠疼痛，减少扭体次数；显著降低二甲苯致小鼠耳肿胀，减少肿胀度；显著抑制λ-角叉菜胶致大鼠足肿胀，减少肿胀度。由此可知，穿心莲内酯磺化物注射液具有明显的解热、镇痛、抗炎的作用。

Abstract:

In order to explore the antipyretic, analgesic and anti-inflammatory effects of andrographolide sulfonide injection, SD rats and KM mice were randomly divided into blank group, positive drug andrographis injection group, and andrographolide sulfonide injection high-, medium- and low-dose groups. The antipyretic effect of dry yeast induced by subcutaneous injection was explored in rats, the analgesic effect of glacial acetic acid induced by twisting body in mice, and the anti-inflammatory effect of xylene-induced ear swelling in mice and λ-carrageenan-induced foot swelling in rats. The results showed that andrographolide sulfonate injection could significantly inhibit the increase of anal temperature in febrile rats induced by dry yeast, significantly inhibit the pain caused by glacial acetic acid and reduce the number of twists, significantly reduce the ear swelling and reduce the swelling degree of mice caused by xylene, and significantly inhibit the foot swelling and reduce the swelling degree of rats induced by λ-carrageenan. It can be seen that andrographolide sulfonate injection has obvious antipyretic, analgesic and anti-inflammatory effects.