卡洛芬注射液辅助治疗牛呼吸道疾病的临床疗效试验

Clinical effect of Carprofen injection in adjuvant treatment of bovine respiratory disease

关键词:  卡洛芬注射液  牛呼吸道疾病  临床疗效

Key words:  Carprofen injection, bovine respiratory disease, clinical effect

摘要:

为了评价卡洛芬注射液辅助治疗牛呼吸道疾病的临床疗效，将卡洛芬注射液分为低、中、高（0.7、1.4、2.8 mg/kg bw）3个剂量组在给予推荐剂量（2.5 mg/kg bw）的泰拉霉素注射液基础上分别给患呼吸道疾病的病牛皮下注射，同时设硕腾公司的卡洛芬注射液为对照组，在给予推荐剂量（2.5 mg/kg bw）的泰拉霉素注射液基础上按1.4 mg/kg bw的剂量给药，另设只皮下注射推荐剂量（2.5 mg/kg bw）的泰拉霉素注射液作为空白对照组。结果表明，卡洛芬注射液与泰拉霉素注射液联用治疗牛呼吸道疾病，与单独使用泰拉霉素注射液相比，可更加快速有效地控制病牛症状，消除炎症反应，提高治疗成功率。卡洛芬注射液中、高剂量的效果无显著差异（P>0.05），与使用推荐剂量硕腾公司生产的卡洛芬注射液的效果相当（P>0.05），均明显优于低剂量的卡洛芬注射液（P<0.05）。卡洛芬注射液按一次量，每1 kg体重1.4 mg皮下注射，与适宜的抗菌药连用，对牛呼吸道疾病有良好的治疗效果。

Abstract:

In order to evaluate the clinical efficacy of carprofen injection in the adjuvant treatment of bovine respiratory disease, carprofen injection was divided into three dose groups of low, medium and high (0.7, 1.4 and 2.8 mg/kg bw) administered subcutaneously to diseased cows suffering from respiratory disease on the basis of tulathromycin injection given at the recommended dose (2.5 mg/kg bw), respectively. While carprofen injection from Zoetis UK Limited was administrated at 1.4 mg/kg bw on the basis of recommended dose (2.5 mg/kg bw) of tulathromycin injection as the control group. The recommended dose (2.5 mg/kgbw) of tulathromycin injection was only injected subcutaneously as a blank control group. The results showed that the combination of carprofen injection and tulathromycin injection for the treatment of bovine respiratory disease could control the symptoms of diseased cows more rapidly and effectively, eliminate the inflammatory response and improve the treatment success rate compared with tulathromycin injection alone. There was no significant difference (P>0.05) in the effect of medium and high doses of carprofen injection, and the effect was comparable (P>0.05) to that of using the recommended dose of carprofen injection produced by Zoetis UK Limited, both of which were significantly better than the low dose of carprofen injection (P<0.05). Carprofen injection at a single dose of 1.4 mg/kg bw subcutaneously, in combination with appropriate antibacterial drugs, had good therapeutic effects on bovine respiratory diseases.