新型异噁唑啉类药物合成研究进展

Research progress in synthesis of new isoxazolines

关键词:  异噁唑啉类药物  寄生虫  合成

Key words:  isoxazolines  parasites  synthesis

摘要:

异噁唑啉类药物是一种新型杀虫剂,主要用于犬和猫体外寄生虫的预防与治疗。目前已上市的异噁唑啉类药物有：Fluralaner、Sarolaner、Afoxolaner和Lotilaner。对以上四种药物的合成方法进行概述,并总结了这些合成方法的优缺点,为该类药物的工业化生产提供一定的参考依据。

Abstract:

The isoxazolines are a new type of insecticides, mainly used for the prevention and treatment of ectoparasites in dogs and cats. The isoxazolines currently in the market include: Fluralaner, Sarolaner, Afoxolaner and Lotilaner. The synthesis methods of the above four drugs are summarized, and the advantages and disadvantages of these synthesis methods are listed, which provide a certain reference basis for the industrial production of such drugs.