固体脂质纳米载体促进药物吸收的研究进展

Research progress on solid lipid nanocarriers promoting drug absorption

关键词:  固体脂质纳米载体，促吸收，影响因素，机制

Key words:  Solid lipid nanocarriers  Promote the absorption  Influence factor  Mechanism of action

摘要:

受到溶解速率、酶和酸碱环境等因素的影响，一些具有良好的药理活性的不溶性药物的使用和吸收会受到一定的限制。药物的吸收效果不仅取决于药物的理化性质，更与其载体系统有关，合适的载体能够促进药物吸收，提高药物的生物利用度，使药物在局部控制释放，以使治疗效果最大化。固体脂质纳米载体可以提高多种药物特别是亲脂化合物的胃肠道吸收和生物利用度，在促进药物的转运和吸收方面具有重要意义。对于固体脂质纳米载体的研究进展以及仍面临的问题，将从作用、影响其促吸收的因素和促吸收的机制等方面进行综述，以指导和推动固体脂质纳米载体在促进药物吸收方面的应用。

Abstract:

In the process of drug development, it is often possible to encounter some drugs with good pharmacological activities, but the use and absorption of these drugs are limited to some extent due to the factors such as dissolution rate, enzyme and acid-base environment, especially insoluble drugs. The absorption of drugs in the body not only depends on the physical and chemical properties of drugs, but also depends on the carrier system. The appropriate carrier can improve the bioavailability, control the release of drugs locally, and maximize the therapeutic effect. Solid lipid nanometer can improve gastrointestinal absorption and bioavailability of many drugs, especially lipophilic compounds. In order to guide and promote the application of solid lipid nanometer in promoting drug absorption, reviewed the research progress of solid lipid nanometer from the aspects of function, influencing factors and mechanism of absorption promotion.