钩吻中非生物碱化学成分的研究进展

Research Progress on Non-alkaloids analysis for chemical constituents from Gelsemium

关键词:  钩吻  非生物碱  环烯醚萜  化学成分

Key words:  Gelsemium  Non-alkaloids  Iridoids  Chemical components

摘要:

钩吻为马钱科植物胡蔓藤的全草,多年生常绿藤本植物,别名野葛、断肠草等。钩吻在传统中药中常用来治疗类风湿性关节炎疼痛,神经性疼痛,痉挛,皮肤溃疡和癌症等,现代医学表明其具有免疫、抗炎镇痛、抗肿瘤等药理活性,其主要活性成分是生物碱。目前,研究表明钩吻中非生物碱成分也具有很强的药理活性。因此,本文对钩吻所含成分中非生物碱的化学成为进行全面综述,详细总结国内外报道的有关环烯醚萜、油脂、三萜,酚酸和甾体等非生物碱化学成分的结构,从而为钩吻化学成分研究和分析研究奠定基础。

Abstract:

Gelsemium elegans is a genus of flowering plants in the Loganiaease family. It is evergreen woody vines and is also known as Gou Wen, Yege, Duan Chang Cao in China. Gelsemium elegans has been used as traditional Chinese medicine for the treatment of rheumatoid arthritis pain, neuropathic pain, spasticity, skin ulcers and cancer for many years. Recently, a number of studies have demonstrated that Gelsemium elegans exhibits a diverse set of immunization, anti-inflammatory, analgesic and anti-tumor activities. Alkaloids are regarded as the major active components of Gelsemium elegans. However, some studies have also showed that non-alkaloid constituents of Gelsemium elegans are responsible for the observed pharmacological effects. Therefore, we provide a comprehensive overview on the non-alkaloid constituents of Gelsemium elegans which have been published. Their structures of non-alkaloid constituents of Gelsemium elegans, including iridoids、oil、triterpene, phenolic acids and steroids, are summarized in this review. The present review will provide the basis for further research of chemical components and analytical methods of Gelsemium elegans.